We identified 873 TNBC patients (Figure 1) who were disease free 5 years after diagnosis and met selection criteria for study inclusion, with a median follow-up of 8.3 years (range, 6.8–10.4 years) from initial diagnosis. The mean age at diagnosis was 51.4 years. Most patients had stage 2 cancer (51.7%), grade 3 disease (88.4%), and invasive ductal histology (90.8%). The other histologic types, in the order of decreasing frequency, were lobular, sarcomatoid, papillary, medullary, and adenocystic. More than 80% of patients had received anthracycline-based chemotherapy. Approximately one-third of patients had received neoadjuvant chemotherapy, and 40.6% of these patients had achieved a pCR. The primary tumour was treated with adjuvant endocrine therapy in 4.5% of patients, predominantly because of either low hormone receptor disease (1–9%) or concurrent HR+ ductal carcinoma in situ. A mastectomy was performed in 59.3% of patients, and 72.2% received adjuvant radiation therapy. Of the 623 (71.3%) patients for whom ER and PR percentage was documented, 76.4% met the current definition of TNBC (ER and PR <1%).
Volume and you can characterisation recently events
Profile dos depicts new collective possibilities of leftover clear of experience for RFI, RFS, and you will DRFS. The fresh new 10-seasons RFI are 97%, RFS 91%, and you can DRFS ninety-five%. The latest 15-year RFI was 95%, RFS 83%, and you will DRFS 84%. Of one’s 873 people, twenty two got later recurrences. 16 (72.7%) of your own recurrences were faraway. Continue reading Table 1 reveals the patient demographic, tumour features, procedures, and you may pathological consequences variables